Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
3.
High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II.
Int J Mol Sci
; 21(15)2020 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32751752
4.
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
J Pharmacol Exp Ther
; 353(1): 119-31, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653417
5.
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.
Drug Metab Dispos
; 40(7): 1429-40, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22517972
6.
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
J Exp Med
; 219(3)2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35226042
7.
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
JCI Insight
; 6(19)2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34622797
8.
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction.
Drug Metab Dispos
; 38(5): 841-50, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20100816
9.
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461332
10.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461331
11.
The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism.
Curr Opin Drug Discov Devel
; 9(1): 101-9, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16445122
12.
A comprehensive listing of bioactivation pathways of organic functional groups.
Curr Drug Metab
; 6(3): 161-225, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15975040
13.
Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.
Chem Biol Interact
; 155(1-2): 10-20, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15978881
14.
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
J Med Chem
; 58(1): 480-511, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469863
15.
A comparison of substrate dynamics in human CYP2E1 and CYP2A6.
Biochem Biophys Res Commun
; 352(4): 843-9, 2007 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17156750
16.
Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Biopharm Drug Dispos
; 27(8): 371-86, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16944451
17.
Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
Chem Res Toxicol
; 18(5): 855-64, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15892579
18.
Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.
Drug Metab Dispos
; 33(2): 243-53, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15523046
19.
Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate.
Biochemistry
; 42(15): 4601-6, 2003 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12693958
20.
Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis.
Toxicol Appl Pharmacol
; 186(2): 119-26, 2003 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12639503